MRE-269 产品活性：MRE-269 是 selexipag 的有效代谢物，同时为选择性的 IP 受体激动剂。 产品来源： https://www.medchemexpress.cn/MRE-269.html 研究领域：GPCR/G Protein 作用靶点：Prostaglandin Receptor 结构分类：酮、醛、酸 | 结构分类 In Vitro: MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-). In Vivo: The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 μM (pEC50, 4.98±0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 μM. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Natural Product Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Angiogenesis-Related Compound Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | Bioactive Compound Library Max | Prostaglandin E2 | EIPA | Prostaglandin E1 | Tranilast | U-46619 | PF-04418948 | Prostaglandin D2 | Dinoprost | Latanoprost | ONO-AE3-208 | Iloprost | Palupiprant | Selexipag | Treprostinil | L-798106 | Grapiprant | 16,16-Dimethyl prostaglandin E2 | DG-041 | Fevipiprant | GW627368 | Laropiprant | Asapiprant | L-161982 | AH 6809 | Ramatroban | RO1138452 | Cefminox sodium | Travoprost | Bimatoprost 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。