Product Introduction
Bioactivity


英文名: CBL0137

描述: CBL0137 (Curaxin 137) 是一种代谢稳定的 curaxin，可激活 p53 (EC50: 0.37 μM) 并抑制 NF-κB (EC50: 0.47 μM)。它在功能上使促进染色质转录复合物 (FACT) 失活，从而驱动对 p53 和 NF-κB 的影响并促进癌细胞死亡。口服 CBL0137 在小鼠体内具有广泛的抗癌活性，可根除耐药性癌症干细胞，并增强吉西他滨在胰腺癌临床前模型中的疗效。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (74.31 mM)
H2O : Insoluble


关键字: CBL 0137 | CBLC 137 | CBLC-137 | CBL0137 | CBL-0137

相关产品: Karacoline | Chicanine | IMD-biphenylC | Kushenol W | 8alpha-Hydroxyhirsutinolide | ALPK1-IN-3 | Anti-osteoporosis agent-4 | Isovitexin | Dendrophenol | Sanggenon C

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Anti-Ovarian Cancer Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Metabolism Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compound Library