中文名:3-甲基腺嘌呤
英文名:3-Methyladenine
英文别名:3-methyladenine|5142-23-4|3-Methyl-3H-purin-6-amine|3-MA|6-Amino-3-methylpurine|3H-Purin-6-amine, 3-methyl-|3-Methyl-3H-adenine|3-methylpurin-6-amine|ADENINE, 3-METHYL-|NSC 66389|C6H7N5|MFCD00010531|3-methyl-7H-purin-6-imine|CHEBI:38635|3-Methyl-d3-adenin
纯度:自噬抑制剂
货号:M486160
Cas号:5142-23-4
产品介绍:
应用
3-甲基腺嘌呤(3-MA)用于抑制和研究多种条件下自噬(溶酶体自我降解)和细胞凋亡的机制。3-MA可通过抑制III型磷脂酰肌醇3-激酶(PI-3K)阻断自噬体的形成来对自噬进行抑制。 3-MA通常以5 mM的浓度用作自噬抑制剂。在癌症生成过程中核酸甲基化检测的标准品。3-Methyladenine has been used as an autophagy inhibitor:to determine the expressions of autophagy-related genes (Beclin 1, light chain 3 (LC3) and p62) using the transfected human bone marrow mesenchymal stem cells (BM-MSCs)with cisplatin to study the inhibition of autophagy influenced cisplatin-induced apoptosis in A2780cp cellsto study the interplay between colistin-induced autophagy and apoptosis
适用性
原理
制备说明
该产品可溶于DMF(10 mg/mL;可能需要温和受热)。 受热情况下,其可以30 mg/ml的浓度溶于水、95%乙醇或1 N NaOH,但在冷却后会从溶液中析出。 可在DMSO中配制100 mM的3-MA溶液。
外形
查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/zh_cn/M486160.html
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