B129693-1g&BAY 11-7082
面议
- 阿拉丁
- 生产商
- B129693-1g
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C10H9NO2S
- 分子量207.25
- MDL号 MFCD00712162
- PubChem编号 24891842
属性
敏感性 | 对热、光和空气敏感 |
溶解性 | Soluble in DMSO (>25 mg/ml), ethanol (15 mg/ml), methanol, dichloromethane, DMF (~25 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Insoluble in water, and sparingly soluble in aqueous buffers. |
存贮条件 | 储存温度 2-8°C ,充氩储存 |
描述
应用 | An anti-inflammatory agent and NFκB inhibitor |
产品介绍 | BAY 11-7082是一种NF-κB抑制剂,抑制TNFα诱导的IκBα磷酸化,IC50为10 μM。同时对泛素化系统的组分也有抑制作用。 |
备注 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
生化机理 | BAY 11-7082, a potential anti-inflammatory agent, is an irreversible inhibitor of IKK α and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM). In intact HUVECs, it inhibits TNFα-induced phosphorylation and degradation of IκBa (NFKBIA) without affecting constitutive phosphorylation. Inhibition of ιBα phosphorylation and degradation results in the inactivation of NFκB and thereby inhibits the expression of endothelial-leukocyte adhesion molecules: E-selectin, VCAM-1 and ICAM-11. BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1. |
别名 | (E)-3-(对甲苯磺酰基)丙烯腈; (E)-3-甲苯磺酰基丙烯腈;(2E)-3-[(4-甲基苯基)磺酰基]-2-丙烯腈;(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile;(E)-3-Tosylacrylonitrile;(E)-3-(p-Toluenesulfonyl)acrylonitrile |
猜你喜欢
感兴趣产品