耗材描述

• 分子式 C₂₅H₂₃N₇OS.HCl
• 分子量506.02

属性

溶解性	DMSO 38 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

应用	A selective SIRT1 activator
产品介绍	SRT1720是一种选择性的SIRT1激活剂，EC50为0.16 μM，比作用于SIRT2和SIRT3效果弱230倍以上。
备注	SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3.
生化机理	SRT1720 is an NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM), highly selective for SIRT1 over SIRT2 or SIRT3. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regulate the cell cycle.
别名	SRT-1720;SRT 1720; N-[2-[3-(1-哌嗪甲基)咪唑并[2,1-b]噻唑-6-基]苯基]-2-喹喔啉甲酰胺盐酸盐;SRT-1720;SRT 1720;SRT 1720 Hydrochloride;N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide hydrochloride

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