| 应用 |
A potent and specific HDAC8 inhibitor. |
| 产品介绍 |
PCI-34051是一种有效的，特异性的HDAC8抑制剂，无细胞试验中IC50为10 nM。比作用于HDAC1和6选择性高200多倍，比作用于HDAC2， 3，和10选择性高1000倍。 |
| 备注 |
PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. |
| 生化机理 |
PCI-34051 is a potent and specific HDAC8 (histone deacetylase 8) inhibitor (IC50 = 10 nM). PCI-34051 reveals greater than 200-fold selectivity over HDAC1 and HDAC6, and greater than 1000-fold selectivity over HDAC2, HDAC3 and HDAC10. |
| 别名 |
PCI 34051; N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺;PCI 34051;PCI34051;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide |
