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JDTic

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

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产品参数
货号 CAS号 操作
J125957-50mg 361444-66-8 询底价
J125957-5mg 361444-66-8 询底价
J125957-10mg 361444-66-8 询底价
产品介绍

  • 分子式 C28H39N3O3
  • 分子量465.63

属性

溶解性 DMSO
存贮条件 储存温度-20°C

描述

生化机理

JDTic is a drug that acts as an opioid antagonist, which is highly selective for the κ-opioid receptor. JDTic blocks this receptor without affecting the μ- or δ-opioid receptors. JDTic is a 4-phenylpiperidine derivative, distantly structurally related to analgesic drugs such as meperidine and ketobemidone, and more closely to the mu opioid antagonist alvimopan, and is structurally distinct from other kappa antagonists such as norbinaltorphimine. JDTic has a very long duration of action, with effects in animals seen for up to several weeks after administration of a single dose, although its binding to the kappa opioid receptor is not irreversible and its long-acting effects are instead caused by altered activity of c-Jun N-terminal kinases. Animal studies suggest that it may produce antidepressant and anxiolytic effects, as well as having possible application in the treatment of addiction to cocaine and morphine.

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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途

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