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G蛋白偶联受体&G蛋白
Plerixafor 8HCl (AMD3100 8HCl)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
AI问答
配套的仪器设备？
可以搭配的相关耗材试剂？
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P129846-10mg | 155148-31-5 | 询底价 |
| P129846-25mg | 155148-31-5 | 询底价 |
| P129846-50mg | 155148-31-5 | 询底价 |
| P129846-5mg | 155148-31-5 | 询底价 |
产品介绍
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A specific CXCR4 antagonist. |
| 产品介绍 | Plerixafor 8HCl (AMD3100 8HCl)是Plerixafor的盐酸盐，是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12调节的趋化性， IC50分别为44 nM和5.7 nM。 |
| 备注 | Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| 生化机理 | AMD3100 octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that AMD3100 octahydrochloride causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that AMD3100 octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, AMD3100 octahydrochloride can also reduce the number of human CD4+ T cells. |
| 别名 | 普乐沙福八盐酸盐;AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride;1,1′-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride |
Plerixafor 8HCl (AMD3100 8HCl)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Plerixafor 8HCl (AMD3100 8HCl)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途
AI问答
