Hemin | 氯化血红素 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 400 |
性能特点
Hemin 是含铁的卟啉化合物。Hemin 是血红素加氧酶 (HO)-1 诱导剂。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 16009-13-5 | ¥400.00 | 询底价 |
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Hemin
CAS No. : 16009-13-5
MCE 国际站:Hemin
产品活性:Hemin 是含铁的卟啉化合物。Hemin 是血红素加氧酶 (HO)-1 诱导剂。
研究领域:Autophagy | Apoptosis
作用靶点:Autophagy | Mitophagy | Ferroptosis
In Vitro: Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment.
In Vivo: Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning.
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• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途