Zinc Protoporphyrin | 锌原卟啉 | MedChemExpress (MCE)

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Zinc Protoporphyrin

CAS No. : 15442-64-5

MCE 国际站：Zinc Protoporphyrin

产品活性：Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的，竞争性的血红素加氧酶-1 (HO-1) 抑制剂，显着减弱间苯三酚 (PG) 对 H₂O₂ 的保护作用。Zinc Protoporphyrin 可用作个体孕妇和儿童缺铁的筛查标志物，也用于评估人群铁状态与血红蛋白浓度的组合。Zinc Protoporphyrin 具有抗癌活性。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Endogenous Metabolite  |  Apoptosis

In Vitro: to increase in Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cytostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in the G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to the accumulation of cleaved (active) caspase-3.

In Vivo: Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.

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