Madecassic acid | 羟基积雪草酸 | MedChemExpress (MCE)

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Madecassic acid

CAS No. : 18449-41-7

MCE 国际站：Madecassic acid

产品活性：Madecassic acid 分离自积雪草(伞形科)。Madecassic acid 具有 iNOS，COX-2，TNF-α，IL-1beta 和 IL-6 抑制作用，可通过在 RAW 264.7 巨噬细胞中下调 NF-κB 激活而具有抗炎作用。

研究领域：Immunology/Inflammation  |  Apoptosis

作用靶点：NO Synthase  |  COX  |  TNF Receptor  |  Interleukin Related

In Vitro: Madecassic acid (150μM, 24 h) inhibits LPS (HY-D1056)-induced iNOS and COX-2 protein expression.

In Vivo: Madecassic acid (p.o, 25 mg/kg, 10 days) reduces the level of IL-17 and the number of γδT17 cells in colon tissues of colitis mice, and attenuates colitis in mice.

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