Artemether | 蒿甲醚 | MedChemExpress (MCE)

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Artemether

CAS No. : 71963-77-4

MCE 国际站：Artemether

产品活性：Artemether是抗疟疾化合物，可作用于恶性疟疾的耐药株。

研究领域：Anti-infection

作用靶点：Parasite

In Vitro: Artemether (0-200 μg/mL, 24-72 h) inhibits rat C6 glioma cell growth in a dose- and time-dependent manner.
Artemether (0-10 μM, 72 h) inhibits RANKL-induced osteoclast (osteoclast precursor cells (BMMs)) formation and related gene expression (TRAP, NFATc1, V-ATPase-d2, CTSK, DC-STAMP, MMP-9).
Artemether (48 or 96 h) inhibits ConA- or alloantigen-induced BALB/c splenocyte proliferation (IC₅₀: 6.3 and 3.5 μM).
Artemether (0-50 μM, 16-36 h) inhibits production of the IL-2 and IFN-γ in BALB/c splenocyte.
Artemether (0-50 μM, 72 h) inhibits ConA-induced splenocyte, CD4+T- and CD8+ T-cell divisions, and inhibits cell cycle progression through G1/S transition.

In Vivo: Artemether (0-66 mg/kg, p.o.) inhibits tumor growth and angiogenesis in SD rats bearing C6 glioma cells.
Artemether (10 mg/kg, i.p., 8 days) protects mice against LPS-induced osteolytic bone loss.
Artemether (50 and 100 mg/kg, p.o.) inhibits T-cell-mediated immune responses (ear swelling) in DNFB-induced DTH model in BALB/c mice.

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