Naringin | 柚皮苷 | MedChemExpress (MCE)

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Naringin

CAS No. : 10236-47-2

MCE 国际站：Naringin

产品活性：Naringin是黄烷酮糖苷，有很多药理作用，例如抗氧化活性，降血脂，抗癌，抑制细胞色素P450酶。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：Cytochrome P450  |  Autophagy  |  Mitophagy  |  Endogenous Metabolite

In Vitro: Naringin suppresses NF-κ B signaling pathway activation. Naringenin inhibits high glucose-induced proliferation, inflammatory reaction and oxidative stress injury in HBZY-1 cells. Naringin inhibits AGS cancer cell proliferation in a dose- and time-dependent manner. Phosphorylation of PI3K and its activated downstream targets p-Akt and p-mTOR are significantly decreased at 2 mM in Naringin-treated AGS cells. Naringin induces autophagic cell death in AGS cells. Naringin activated the autophagy related protein in AGS cells. Naringin protects PC12 cells from 3-NP neurotoxicity. The lactate dehydrogenase release is decreased upon naringin treatment in 3-NP-induced PC12 cells. Naringin treatment enhances the antioxidant defense by increasing the activities of enzymatic antioxidants and the level of reduced glutathione.

In Vivo: Treatment with naringin significantly alleviates renal injury in diabetic rats and increases diabetic rats body weight significantly. Administration of naringin effectively alleviates the collagen deposition and renal interstitial fibrosis in diabetic rats. Treatment with naringin could result in decreased levels of ROS and MDA and increased activities of SOD and GSH-Px. Oral administration of naringin significantly improves the learning and memory abilities. Naringin significantly enhances insulin signaling pathway.

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