Anastrozole | 阿那曲唑 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 528 |
性能特点
Anastrozole 是一种选择性的芳香酶 (aromatase) 抑制剂,抑制胎盘芳香化酶,IC50 为 15 nM。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 120511-73-1 | ¥528.00 | 询底价 |
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Anastrozole
CAS No. : 120511-73-1
MCE 国际站:Anastrozole
产品活性:Anastrozole 是一种选择性的芳香酶 (aromatase) 抑制剂,抑制胎盘芳香化酶,IC50 为 15 nM。
研究领域:Metabolic Enzyme/Protease
作用靶点:Cytochrome P450
In Vitro: Anastrozole is a comparatively simple, achiral benzyltriazole derivative, that inhibits human placental aromatase with an IC50 of 15 nM. In the same assay it is 200 times as potent as aminoglutethimide (AG), twice as potent as 4-OHA and one third as potent as Fadrozole.
In Vivo: Groups of eight immature (22-day-old) female rats are given androstenedione (AD) (30 mg/kg) in arachis oil s.c. daily for 3 days with or without various doses of Anastrozole p.o. on day 4 the uteri are dissected, blotted and weighed. An oral dose of 0.1 mg/kg of Anastrozole given on day 2 or day 3 of the cycle completely blocked ovulation. At the same daily dosage (0.1 mg/kg), Anastrozole completely extinguished the uterotrophic activity of exogenous AD in immature rats. In male pigtailed monkeys, twice-daily oral treatment with 0.1 mg/kg and above of Anastrozole reduced circulating oestradiol concentrations by 50-60%.
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