Donepezil Hydrochloride | 盐酸多奈哌齐 | MedChemExpress (MCE)

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Donepezil Hydrochloride

CAS No. : 120011-70-3

MCE 国际站：Donepezil Hydrochloride

产品活性：Donepezil Hydrochloride (E2020) 是一种可逆的选择性 AChE 抑制剂，对AChE 的 IC₅₀ 为 6.7 nM。对 AChE 的选择性高于 BuChE。Donepezil Hydrochloride对 Aβ42 神经毒性具有神经保护作用。

研究领域：Neuronal Signaling

作用靶点：Cholinesterase (ChE)

In Vitro: Donepezil’s neuroprotective mechanism is related to the enhanced phosphorylation of Akt and GSK-3β and reduced phosphorylation of tau and glycogen synthase.

In Vivo: Donepezil treatment (3 mg/kg) significantly prevents the progression of scopolamine-induced memory impairment in mice.
A pharmacokinetic study of Donepezil shows a mean peak plasma concentration of donepezil after oral treatment (3 and 10 mg/kg) of approximately 1.2 h and 1.4 h, respectively; absolute bioavailability is calculated as 3.6%.

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