Ibuprofen | 布洛芬 | MedChemExpress (MCE)

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Ibuprofen

CAS No. : 15687-27-1

MCE 国际站：Ibuprofen

产品活性：Ibuprofen ((±)-Ibuprofen) 是一种口服有效的 COX-1 选择性抑制剂，IC₅₀ 值为 13 μM。Ibuprofen 抑制细胞增殖、血管生成，并诱导细胞凋亡 (apoptosis)。Ibuprofen 是一种非甾体抗炎试剂和一氧化氮 (NO) 供体。Ibuprofen可用于疼痛、肿胀、炎症、感染、免疫学、癌症的研究。

研究领域：Immunology/Inflammation  |  Apoptosis  |  Anti-infection

作用靶点：COX  |  Apoptosis  |  Parasite

In Vitro: Ibuprofen (24 h) inhibits COX-1 and COX-2 activity with IC₅₀ values of 13 μM and 370 μM.
? Ibuprofen (500 μM, 48 h) inhibits cell proliferation and angiogenesis, and induces apoptosis in AGS cells (Adenocarcinoma gastric cell line).
? Ibuprofen (500 μM, 48 h) downregulates transcription of Akt, VEGF-A, PCNA, Bcl2, OCT3/4 and CD44 genes, but upregulates RNA levels of wild type P53 and Bax genes in AGS cell.
? Ibuprofen (500 μM, 24 h) restores microtubule reformation, microtubule-dependent intracellular cholesterol transport, and induces extension of microtubules to the cell periphery in both cystic fibrosis (CF) cell models and primary CF nasal epithelial cells.
? Ibuprofen (500 μM, 24 h) enhances UV-induced cell death in MCF-7 cells and MDA-MB-231 cells by a photosensitization process.

In Vivo: Ibuprofen (300 mg/kg; p.o.; daily, for 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer.
? Ibuprofen (60 mg/kg; i.h.; every second day for 15 days) reduces the risk of neuropathy in a rat model of chronic Oxaliplatin?induced peripheral neuropathy.
? Ibuprofen (20 mg/kg; p.o.; every 12 hours, 5 doses total) decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise.
? Ibuprofen (35 mg/kg; p.o.; twice daily) attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection.

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