SM1-71 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 820 |
性能特点
SM1-71 是一种有效的 TAK1 抑制剂,Ki 值为 160 nM,同时可以共价抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAP
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 2088179-99-9 | ¥820.00 | 询底价 |
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SM1-71
CAS No. : 2088179-99-9
MCE 国际站:SM1-71
产品活性:SM1-71 是一种有效的 TAK1 抑制剂,Ki 值为 160 nM,同时可以共价抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 在体外抑制多种癌细胞系的增殖。
研究领域:MAPK/ERK Pathway | Protein Tyrosine Kinase/RTK | Cell Cycle/DNA Damage
作用靶点:MAP3K | Src | FGFR | Ribosomal S6 Kinase (RSK) | LIM Kinase (LIMK)
In Vitro: SM1-71 (0.001-100 μM; 72 h) potently inhibits the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines with a concentration-dependent manner.
SM1-71 (72 h) induces potent cytotoxicity with nanomolar values for GR50 and negative GRmax values in eight of 11 cancer cell lines.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Protein Tyrosine Kinase Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glutamine Metabolism Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Anti-Liver Cancer Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Osteogenesis Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Cysteine Targeted Covalent Library | Cytokine Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Multi-Target Compound Library | Dasatinib | Lenvatinib | Regorafenib | Nintedanib | Ponatinib | Erdafitinib | Infigratinib | Pemigatinib | Saracatinib | Bosutinib | PP2 | Pazopanib | Futibatinib | Heparan Sulfate | Fexagratinib | Formononetin | PD173074 | Takinib | BI-D1870 | 5Z-7-Oxozeaenol | SU 5402 | Rebastinib | Selonsertib | PF-4708671 | Carnosol | WH-4-023 | Masitinib | Dovitinib
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