Manidipine dihydrochloride | 盐酸马尼地平 | MedChemExpress (MCE)

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Manidipine dihydrochloride

CAS No. : 89226-75-5

MCE 国际站：Manidipine dihydrochloride

产品活性：Manidipine dihydrochloride 是一种第三代、亲脂性、口服有效且高血管选择性的钙通道 (calcium channel) 拮抗剂 (IC₅₀ = 2.6 nM, 于豚鼠心室细胞中) 与抗高血压剂。Manidipine 能有效降低血压，兼具提高胰岛素敏感度，肾脏保护和抗动脉粥样硬化活性。Manidipine 还发挥出由 NF-κB 介导的抗炎活性以及通过抑制钙通道对多种黄病毒和负链 RNA 病毒具备的抗病毒活性。美尼地平被广泛应用于心血管、代谢性疾病和感染的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  NF-κB

作用靶点：Calcium Channel  |  NF-κB

In Vitro: Manidipine dihydrochloride (1 μM, 42 h) suppresses IL-6 secretion in lipoproteins-induced HUVEC.
Manidipine dihydrochloride (1 μM, 16 h) suppresses IL-6 secretion in 10 ng/mL IL-1, 10 ng/mL IFN-γ, and 25 ng/mL TNFα treated THP-I .
Manidipine dihydrochloride (20 mg/mL, 48/20 h) inhibits propagation/genome replication of SFTSV (a negative-strand RNA virus) in SW13 cells.
Manidipine dihydrochloride (20 mg/mL, 48 h) interferes SFTSV N-induced inclusion body formation in Huh-7 cells.

In Vivo: Manidipine dihydrochloride (10 mg/kg, i.p., b.i.d. at day 4, day 5) prolongs survival in SFTSV-infected mice.
Manidipine dihydrochloride (25 mg/kg, i.p., b.i.d. for 2 d, then daily for 19 d) protects mice from JEV infection.
Manidipine dihydrochloride (3 mg/kg, i.g., once per day, 7 d) prevents isoproterenol-induced left ventricular hypertrophy in rats.

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