Dirithromycin | 地红霉素 | MedChemExpress (MCE)

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Dirithromycin

CAS No. : 62013-04-1

MCE 国际站：Dirithromycin

产品活性：Dirithromycin (LY237216)，一种红霉素的衍生物，是一种有效和具有口服活性的半合成大环内酯类抗生素。Dirithromycin 对革兰氏阳性菌，Legionella spp.，Helicobacter pylori 和 Chlamydia trachomatis 具有活性。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin.
Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and <0.25 μg/mL at pH=7.1 and 7.4, respectively.
Dirithromycin demonstrates potent activity against several strains of Helicobacter pytori, with MICs of <0.5 μg/mL.

In Vivo: Dirithromycin (s.c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED₅₀s of 1.0, 0.6, and <0.6 mg/kg.
Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED₅₀s of 27, 34, and 23 mg/kg.

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