Clemizole hydrochloride | 盐酸克立咪唑 | MedChemExpress (MCE)

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Clemizole hydrochloride

CAS No. : 1163-36-6

MCE 国际站：Clemizole hydrochloride

产品活性：Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂，抑制 HCV 复制。Clemizole hydrochloride 还是一种 TRPC5 通道的抑制剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation  |  Membrane Transporter/Ion Channel  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Histamine Receptor  |  TRP Channel  |  HCV Protease  |  HCV

In Vitro: Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC₅₀ of Clemizole on the W55R mutant J6/JFH RNA is ~18 µM (2.25 times the EC₅₀ of the wild-type RNA). Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca²⁺ entry in the low micromolar range (IC₅₀=1.0-1.3 µM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC₅₀=6.4 µM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC₅₀=9.1 µM) and TRPC6 (IC₅₀=11.3 µM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 µM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC₅₀ of 1.1±0.04 µM.

In Vivo: Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  Drug Repurposing Compound Library  |  Endocrinology Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Hepatitis C Virus Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Anti-Obesity Compound Library  |  Mechanoreceptors Compound Library  |  Targeted Diversity Library  |  Rare Diseases Drug Library  |  FDA-Approved Anticancer Drug Library  |  Coagulation and Anti-coagulation Compound Library  |  Heterocyclic Compound Library  |  Pain-Related Compound Library  |  Off-patent Drug Library  |  Protease Inhibitor Library   |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Ion Channel Compound Library  |  Multi-Target Compound Library  |  Rosiglitazone  |  Resiquimod  |  Capsaicin  |  GsMTx4  |  EIPA  |  Probenecid  |  2-Aminoethyl diphenylborinate  |  Diphenyleneiodonium chloride  |  Histamine  |  Amiloride hydrochloride  |  GSK1016790A  |  Honokiol  |  Capsazepine  |  Deferiprone  |  Ribavirin  |  U18666A  |  HC-067047  |  Artemisinin  |  AG-1478  |  HC-030031  |  Asunaprevir  |  Grazoprevir  |  ML-SA1  |  Myriocin  |  EIDD-1931  |  Sofosbuvir  |  GSK2193874  |  NIM811  |  Simeprevir

热门产品线：重组蛋白  |  药物筛选  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。