Orexin B, rat, mouse TFA | MedChemExpress (MCE)

Orexin B, rat, mouse TFA 产品活性：Orexin B, rat, mouse (Rat orexin B) TFA 是一种内源性增食欲素受体 (Orexin receptor) 激动剂。Orexin B, rat, mouse TFA 结合并激活两个密切相关的孤儿 G 蛋白偶联受体 OX1-R 和 OX2-R。Orexin B, rat, mouse TFA 刺激食物摄入和能量消耗，并在睡眠-觉醒调节中发挥重要作用。 产品来源： https://www.medchemexpress.cn/orexin-b-rat-mouse-tfa.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Orexin Receptor (OX Receptor) In Vitro: OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively. In Vivo: Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo. 相关产品：Orexin A (human, rat, mouse) (TFA) | Danavorexton | Almorexant | SB-334867 free base | YNT-185 dihydrochloride | Seltorexant | EMPA | JNJ-10397049 | Orexin 2 Receptor Agonist | SB-674042 | Filorexant | Orexin B, human TFA | SB-649868 | MK-1064 | OXA(17-33) | TCS 1102 | TCS-OX2-29 | Cudarolimab | ACT-462206 | GSK1059865 | Revdofilimab | Firazorexton | Orexin B, rat, mouse | RTIOXA-43 | SB-408124 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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