HS014 | MedChemExpress (MCE)

HS014 产品活性：HS014 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM。HS014 调节吗啡对小鼠行为的影响。HS014 增加自由喂养大鼠的食物摄取量。 产品来源： https://www.medchemexpress.cn/hs014.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Melanocortin Receptor In Vivo: The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively. Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate. 相关产品：α-MSH | Melanotan I | SHU 9119 | BMS-470539 dihydrochloride | Bremelanotide Acetate | Nonapeptide-1 acetate salt | JNJ-10229570 | THIQ | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA | HS024 TFA | β-Melanocyte Stimulating Hormone (MSH), human TFA | Dersimelagon | MK-0493 | PF-00446687 | SNT-207707 | ACTH (1-17) (TFA) | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) | MSG606 | SNT-207858 free base | [D-Trp8]-γ-MSH | Adrenocorticotropic Hormone (ACTH) (4-10), human | Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA) | Fenoprofen | PF-07258669 | ACTH (11-24) | HS014 TFA | ML-00253764 hydrochloride | PG-931 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途