Pogostone | MedChemExpress (MCE)

Pogostone 产品活性：Pogostone 从广藿香油中分离出，具有抗菌和抗癌活性。 Pogostone 抑制革兰氏阴性菌和革兰氏阳性菌，也表现出对干燥杆菌的抑制作用，MIC 值为 0.098 µg /ml。 Pogostone 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。 产品来源： https://www.medchemexpress.cn/pogostone.html 研究领域：Anti-infection | Apoptosis | Autophagy 作用靶点：Bacterial | Apoptosis | Autophagy 来源：植物 | 菊科 | 毛连菜 | 植物 | 唇形科 结构分类：其他类 | 结构分类 In Vitro: Pogostone?shows inhibitory effects on HCT116 cell with an IC50 value of 18.7±1.93 μg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC50: 95.13±19.44 μg/ml) and endothelial cell HUVEC (IC50: 112±20.77 μg/ml). In Vivo: Pogostone?( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Natural Product Library | Autophagy Compound Library | Antibacterial Compound Library | Medicine Food Homology Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Cysteine Targeted Covalent Library | Cell Death Library | Bioactive Compound Library Max | MG-132 | Rapamycin | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Dimethyl sulfoxide | Y-27632 | LY294002 | Paclitaxel | Dexamethasone | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Puromycin dihydrochloride | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途