Isorhamnetin | 异鼠李素 | MedChemExpress (MCE)

Isorhamnetin 产品活性：Isorhamnetin 是从中草药沙棘 (Hippophae rhamnoides L.) 中提取的类黄酮化合物。Isorhamnetin 可通过直接抑制 MEK1 和 PI3K 来抑制皮肤癌。 产品来源： https://www.medchemexpress.cn/Isorhamnetin.html 研究领域：MAPK/ERK Pathway | PI3K/Akt/mTOR | Metabolic Enzyme/Protease 作用靶点：MEK | PI3K | Endogenous Metabolite 来源：植物 | 豆科 | 甘草 | 植物 | 胡颓子科 | 沙棘 结构分类：黄酮类 | 黄酮醇 | 酚类 | 多酚类 | 结构分类 In Vitro: Isorhamnetin is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin binds directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner. In vitro and ex vivo kinase assay data show that Isorhamnetin inhibits the kinase activity of MAP/ERK kinase (MEK) 1 and PI3-K and the inhibition is due to direct binding with Isorhamnetin. Isorhamnetin inhibits the Akt/mTOR and MEK/ERK signaling pathways, and promotes the activity of the mitochondrial apoptosis signaling pathway. The inhibitory effects of Isorhamnetin on breast cancer cells are determined using the CCK-8 method. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC50, ~10 µM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC50, 38 µM). In Vivo: Photographic data shows that Isorhamnetin treatment suppresses tumor development in mice. The average volume of tumors in untreated mice increases over time and reaches a volume of 623 mm3 at 4 weeks post-inoculation; however, at this time, in mice treated with 1 or 5 mg/kg Isorhamnetin, the average tumor volume is only 280 or 198 mm3, respectively. At the end of the study, Isorhamnetin treatment (1 or 5 mg/kg) reduces tumor weight compared with the untreated control group. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Metabolism/Protease Compound Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Human Endogenous Metabolite Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Ferroptosis Compound Library | Medicine Food Homology Compound Library | Phenols Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Flavonoids Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Glucose Metabolism Compound Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Animal-Sourced Natural Product Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Anti-Fibrosis Compound Library | Rapamycin | 3-Methyladenine | LY294002 | Acetylcysteine | 5-Fluorouracil | Trametinib | ATP | Retinoic acid | Hydrocortisone | Estradiol | Quercetin | Nicotinamide | Alpelisib | Prostaglandin E2 | PD98059 | AICAR | Palmitic acid | Docetaxel | Isoprenaline hydrochloride | L-Ascorbic acid | Mirdametinib | Cytarabine | 740 Y-P | Melatonin | Calcitriol | Capsaicin | Wortmannin | Arachidonic acid | Valproic acid | U0126-EtOH 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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