Orexin A (human, rat, mouse) | MedChemExpress (MCE)

Orexin A (human, rat, mouse) 产品活性：Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) 是一种 33 氨基酸兴奋性神经肽，参与多种中枢和外周过程。Orexin A (human, rat, mouse) 是一种特异性、高亲和力的 G 蛋白偶联受体 OX1R 激动剂，在调节摄食行为中起重要作用。Orexin A (human, rat, mouse) 是一种有效的抗伤害和抗痛觉过敏的活性分子。 产品来源： https://www.medchemexpress.cn/Rat_orexin_A.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Orexin Receptor (OX Receptor) In Vitro: Orexin A (human, rat, mouse) has high affinity for OX1R, with 38 nM IC50 and 34 nM EC50 values in the the [Ca2﹢]i transient assay. In Vivo: Orexin A (human, rat, mouse) (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively. Orexin A (human, rat, mouse) (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg. 相关产品：Bioactive Compound Library Plus | Peptide Library | Orexin A (human, rat, mouse) (TFA) | Danavorexton | Almorexant | SB-334867 free base | YNT-185 dihydrochloride | Seltorexant | EMPA | JNJ-10397049 | Orexin 2 Receptor Agonist | SB-674042 | Filorexant | Orexin B, human TFA | SB-649868 | MK-1064 | OXA(17-33) | TCS 1102 | TCS-OX2-29 | Cudarolimab | ACT-462206 | GSK1059865 | Revdofilimab | Firazorexton | Orexin B, rat, mouse | RTIOXA-43 | SB-408124 | Vornorexant 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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