Allopurinol riboside | 别嘌呤醇核糖苷 | MedChemExpress (MCE)

Allopurinol riboside 产品活性：Allopurinol riboside是别嘌呤醇的代谢物，能有效地抑制寄生虫。 产品来源： https://www.medchemexpress.cn/Allopurinol_riboside.html 研究领域：Anti-infection | Metabolic Enzyme/Protease 作用靶点：Parasite | Drug Metabolite | Endogenous Metabolite 结构分类：生物碱 | 吲哚类生物碱 | 结构分类 In Vitro: Allopurinol-riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM. Lymphocyte blastogensis induced by PHA and Con A is significantly suppressed by allopurinol-riboside in a concentration-dependent manner. When LPS is used as a mitogen, the inhibition of allopurinol-ribosideon lymphocyte proliferation is less marked. Humoral immunity is not suppressed by allopurinol-riboside. Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Allopurinol riboside is effective against parasites, because a series of enzymes (analogous to those that mediate purine salvage in humans) convert it into 4-aminopyrazolopyrimidine ribonucleoside triphosphate, a cytotoxic product. Allopurinol riboside is selectively toxic, because it is not metabolized by the corresponding enzymes in humans. In Vivo: Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma. 相关产品：Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Metabolism/Protease Compound Library | Natural Product Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Glycoside Compound Library | Nucleotide Compound Library | FDA Approved & Pharmacopeial Drug Library | Alkaloids Library | Antiparasitic Compound library | Food-Sourced Compound Library | Drug Metabolite Library | Rare Diseases Drug Library | Human Metabolite Library | Heterocyclic Compound Library | Off-patent Drug Library | Bioactive Compound Library Max | Rapamycin | 3-Methyladenine | Chloroquine | Acetylcysteine | Puromycin dihydrochloride | 5-Fluorouracil | ATP | Retinoic acid | Hydrocortisone | Estradiol | Nicotinamide | Prostaglandin E2 | AICAR | Hygromycin B | Palmitic acid | Docetaxel | Isoprenaline hydrochloride | L-Ascorbic acid | Clozapine N-oxide | Cytarabine | Doxycycline hyclate | Melatonin | Calcitriol | Capsaicin | Arachidonic acid | Valproic acid | Oleic acid | β-Nicotinamide mononucleotide | Acetaminophen 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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