Maxacalcitol | 马沙骨化醇 | MedChemExpress (MCE)

Maxacalcitol 产品活性：Maxacalcitol (22-Oxacalcitriol) 是一种维生素 D3 (HY-15398) 类似物，是一种具有口服活性的 VDR 激动剂。Maxacalcitol 具有有限的降钙作用。Maxacalcitol 具有用于牛皮癣和甲状旁腺功能亢进研究的潜力。 产品来源： https://www.medchemexpress.cn/Maxacalcitol.html 研究领域：Vitamin D Related/Nuclear Receptor 作用靶点：VD/VDR In Vitro: Maxacalcitol (22-Oxacalcitriol; 100 nM; for 24 h) markedly increases the expression of LL-37 mRNA in Ca9-22 cells and modestly but significantly increases in HSC-2, HSC-3, and HSC-4 cells. In Vivo: Maxacalcitol (22-Oxacalcitriol; oral gavage; 15 µg/kg/day; 14 days) followed by GSK 269962 at a single dose of 10 mg/kg, leads to a statistically significant reduction of intercontraction interval and bladder compliance, and an increase in DO index, without any effect on ANVC, FNVC, and VTNVC. Maxacalcitol in a dose of 30 but not 15 µg/kg/day induced reduction in detrusor overactivity (DO) index, non-voiding contractions frequency (FNVC), and amplitude (ANVC), while increasing volume threshold to elicit non-voiding contractions (VTNVC). 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | Bioactive Compound Library Plus | Calcipotriol | Calcitriol | Vitamin D3 | Tachysterol 3 | Calcifediol | Paricalcitol | MeTC7 | Vitamin D2 | Eldecalcitol | Ercalcidiol | Alfacalcidol | Secalciferol | Ercalcitriol | TEI-9647 | Seocalcitol | VD3-d6 | Inecalcitol | ZK168281 | Vitamin D4 | 24, 25-Dihydroxy VD2 | Calcitetrol | Tacalcitol | 5,6-trans-Vitamin D3 | Doxercalciferol | VD2-d3 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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