PNU-120596 | MedChemExpress (MCE)

PNU-120596 产品活性：PNU-120596 (NSC 216666) 是一种有效的选择性 α7 nAChR 阳性变构调节剂，EC50 为 216 nM。PNU-120596 对 α4β2，α3β4 和 α9α10 nAChRs 无活性。PNU-120596 可用于精神病和神经疾病的研究。 产品来源： https://www.medchemexpress.cn/PNU-120596.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：nAChR In Vitro: PNU-120596 increases agonist-evoked calcium flux mediated by an engineered variant of the human α7 nAChR. Electrophysiology studies confirme that PNU-120596 increases peak agonist-evoked currents mediated by wild-type receptors and also demonstrates a pronounced prolongation of the evoked response in the continued presence of agonist. PNU-120596 increases the channel mean open time of α7 nAChRs. ? When applied to acute hippocampal slices, PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents measured in pyramidal neurons. ? PNU-120596 enhances agonist-evoked gating of nicotinic receptors by eliciting conformational effects that are similar but nonidentical to the gating conformations promoted by ACh. In Vivo: PNU-120596 (1 mg/kg; intravenous injection; once) treatment improves the auditory gating deficit caused by Amphetamine in rats, a model proposed to reflect a circuit level disturbance associated with schizophrenia.? When administered before carrageenan, NU-120596 (30 mg/kg; i.p.) significantly reduces mechanical hyperalgesia and weight-bearing deficits for up to 4 h in Sprague-Dawley rats. PNU-120596 attenuates the carrageenan-induced increase in levels of TNF-α and IL-6 within the hind paw oedema. 相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | CNS-Penetrant Compound Library | Covalent Screening Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | Ion Channel Compound Library | Allosteric Modulators (AMs) Compound Library | Bioactive Compound Library Max | Acetylcholine chloride | Methyllycaconitine citrate | PNU-282987 | Carbamoylcholine chloride | GTS-21 dihydrochloride | Mecamylamine hydrochloride | Choline chloride | Benzethonium chloride | COG 133 TFA | D-Tubocurarine chloride pentahydrate | α-Bungarotoxin | Arecoline hydrobromide | Varenicline | Spinosad | Anabasine | Rocuronium Bromide | Levamisole | Hydroxybupropion | Lobeline hydrochloride | Monepantel | Cisatracurium besylate | Dequalinium Chloride | Hexamethonium Bromide | Pancuronium dibromide | PHA-543613 | Vecuronium bromide | Adiphenine hydrochloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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