5-R-Rivaroxaban | 5-R-利伐沙班 | MedChemExpress (MCE)

5-R-Rivaroxaban 产品活性：5-R-Rivaroxaban 是 Rivaroxaban 的 R 型对映体。Rivaroxaban (BAY 59-7939) 是一种有效的选择性 Factor Xa (FXa) 抑制剂。 产品来源： https://www.medchemexpress.cn/5-r-rivaroxaban.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Factor Xa In Vitro: Rivaroxaban (BAY 59-7939) is an oral, direct Factor Xa (FXa) inhibitor in development for the prevention and treatment of arterial and venous thrombosis. Rivaroxaban competitively inhibits human FXa (Ki 0.4 nM) with >10 000-fold greater selectivity than for other serine proteases; it also inhibits prothrombinase activity (IC50 2.1 nM). Rivaroxaban inhibits endogenous FXa more potently in human and rabbit plasma (IC50 21 nM) than rat plasma (IC50 290 nM). It demonstrates anticoagulant effects in human plasma, doubling prothrombin time (PT) and activates partial thromboplastin time at 0.23 and 0.69 μM, respectively. In Vivo: Rivaroxaban (BAY 59-7939) is a potent and selective, direct FXa inhibitor with excellent in vivo activity and good oral bioavailability. Rivaroxaban (BAY 59-7939), administered by i.v. bolus before thrombus induction, reduces thrombus formation (ED50 0.1 mg/kg), inhibits FXa, and prolongs PT dose dependently. PT and FXa are affected slightly at the ED50 (1.8-fold increase and 32% inhibition, respectively). At 0.3 mg/kg (dose leading to almost complete inhibition of thrombus formation), Rivaroxaban moderately prolongs PT (3.2±0.5-fold) and inhibits FXa activity (65±3%). 相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cardiovascular Disease Compound Library | Targeted Diversity Library | Coagulation and Anti-coagulation Compound Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | Heparin sodium salt | Apixaban | Rivaroxaban | Asundexian | Edoxaban | Fondaparinux sodium | Milvexian | Enoxaparin | Gabexate mesylate | Betrixaban | Abelacimab | Garadacimab | Fitusiran | Otamixaban | Bismuth subgallate | BMS-262084 | BMS-962212 | Darexaban | Ciraparantag | Osocimab | D-Pro-Phe-Arg-Chloromethylketone | Dechloro Rivaroxaban | Frunexian | ARC19499 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

5-R-Rivaroxaban | 5-R-利伐沙班 | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供，如您想了解更多关于5-R-Rivaroxaban | 5-R-利伐沙班 | MedChemExpress (MCE)报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途