SD-208 | MedChemExpress (MCE)

SD-208 产品活性：SD-208 是一种选择性的 TGF-βRI (ALK5) 抑制剂，IC50 值为 48 nM，对其选择性是对 TGF-βRII 的 100 多倍。 产品来源： https://www.medchemexpress.cn/SD-208.html 研究领域：TGF-beta/Smad 作用靶点：TGF-β Receptor In Vitro: SD-208 inhibits the cell growth and constitutive and TGF-beta-evoked migration and invasion, and enhances immunogenicity in murine SMA-560 and human LN-308 glioma cells. SD-208 blocks TGF-beta-induced phosphorylation of the receptor-associated Smads, Smad2 and Smad3, and stimulates epithelial-to-mesenchymal transdifferentiation, migration, and invasiveness into Matrigel in vitro. SD-208 also abolishes the promoting effect of TGF-β on neointimal smooth muscle-like cell (SMLC) proliferation and migration in vitro. In Vivo: SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA). 相关产品：Bioactive Compound Library Plus | Kinase Inhibitor Library | TGF-beta/Smad Compound Library | Anti-Cancer Compound Library | Reprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Targeted Diversity Library | Anti-Colorectal Cancer Compound Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Osteogenesis Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Cytokine Inhibitors Library | Bioactive Compound Library Max | Anti-Fibrosis Compound Library | SB-431542 | Dorsomorphin | A 83-01 | Galunisertib | LDN193189 | RepSox | DMH-1 | LY2109761 | SB 525334 | Vactosertib | BMP signaling agonist sb4 | SB-505124 | Bimagrumab | LY-364947 | LSKL, Inhibitor of Thrombospondin (TSP-1) | GW788388 | ITD-1 | LDN-212854 | LY3200882 | LDN-214117 | R-268712 | ML347 | Fresolimumab | Cetrimonium bromide | SJ000291942 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

SD-208 | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供，如您想了解更多关于SD-208 | MedChemExpress (MCE)报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途