Granisetron | 格拉司琼 | MedChemExpress (MCE)

Granisetron 产品活性：Granisetron (BRL 43694) 是5-HT3受体拮抗剂。 产品来源： https://www.medchemexpress.cn/Granisetron.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：5-HT Receptor In Vitro: In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT. In Vivo: Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation. 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Antiviral Compound Library | Drug Repurposing Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Targeted Diversity Library | Children’s Drug Library | EMA-Approved Drug Library | 5-HT Receptor Compound Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Coagulation and Anti-coagulation Compound Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | Chlorpromazine hydrochloride | Serotonin hydrochloride | SCH-23390 hydrochloride | Harmine | Puerarin | PNU-282987 | Scopolamine hydrobromide | Clozapine | Risperidone | Vortioxetine | Olanzapine | Dihydroergotamine mesylate | Aripiprazole | GTS-21 dihydrochloride | Amitriptyline hydrochloride | Ondansetron | Thioridazine hydrochloride | Brexpiprazole | SB-269970 hydrochloride | Cisapride | SEP-363856 hydrochloride | Volinanserin | Vilazodone Hydrochloride | Pimavanserin | 8-OH-DPAT | Ketanserin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途