JW 55 | MedChemExpress (MCE)

JW 55 产品活性：JW 55 是一种有效的选择性 β-catenin 抑制剂，通过抑制端锚聚合酶 (tankyrase 1 和 tankyrase 2，TNKS1/2) 发挥作用。 产品来源： https://www.medchemexpress.cn/JW-55.html 研究领域：Cell Cycle/DNA Damage | Epigenetics 作用靶点：PARP In Vitro: JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. In Vivo: JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication inXenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice. 相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Highly Selective Inhibitors Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Olaparib | XAV-939 | Talazoparib | Niraparib | Saruparib | Rucaparib | Veliparib | Chlorin e6 | PJ34 | RBN-2397 | Pamiparib | Fucosterol | Patritumab | Dehydrocorydaline | Fluzoparib | RBN012759 | AG14361 | 3-Aminobenzamide | G007-LK | Daphnetin | NVP-TNKS656 | Rucaparib monocamsylate | Paris saponin VII | AZD-2461 | DPQ 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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