PNU-282987 | MedChemExpress (MCE)

PNU-282987 产品活性：PNU-282987 是一种有效的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，EC50 为 154 nM。PNU-282987 也是 5-HT3 受体的功能性拮抗剂，IC50 为 4541 nM。PNU-282987 可用于中枢和外周神经系统的研究。 产品来源： https://www.medchemexpress.cn/PNU-282987.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | GPCR/G Protein 作用靶点：nAChR | 5-HT Receptor In Vitro: PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM. PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM. PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM. In Vivo: PNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit. PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner. 相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | 5-HT Receptor Compound Library | Coagulation and Anti-coagulation Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Acetylcholine chloride | Methyllycaconitine citrate | Chlorpromazine hydrochloride | Serotonin hydrochloride | SCH-23390 hydrochloride | Harmine | Puerarin | Scopolamine hydrobromide | Clozapine | Carbamoylcholine chloride | Risperidone | Vortioxetine | Olanzapine | Dihydroergotamine mesylate | Aripiprazole | GTS-21 dihydrochloride | Amitriptyline hydrochloride | Ondansetron | Mecamylamine hydrochloride | Thioridazine hydrochloride | Brexpiprazole | SB-269970 hydrochloride | Cisapride | SEP-363856 hydrochloride | Volinanserin | Vilazodone Hydrochloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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