PF 05089771 | MedChemExpress (MCE)

PF 05089771 产品活性：PF 05089771是有效的、具有口服活性的、选择性的 Nav1.7 丙烯酰胺抑制剂，其对 hNav1.7、cynNav1.7、dogNav1.7、ratNav1.7 和 musNav1.7 的 IC50 值分别为11 nM、12 nM、13 nM、171 nM 和 8 nM。PF 05089771 目前正用于疼痛和糖尿病神经性疾病的研究。 产品来源： https://www.medchemexpress.cn/PF-05089771.html 研究领域：Membrane Transporter/Ion Channel 作用靶点：Sodium Channel In Vitro: PF-05089771 is determined to be more than 1000-fold selective over tetrodotoxin-resistant (TTX-R) Nav1.5 and Nav1.8 channels (IC50s >10 μM) and exhibited a range of selectivity over TTX-sensitive (TTX-S) channels (10-fold for Nav1.2 to 900-fold for Nav1.3 and Nav1.4). PF-05089771 (30 nM) blocks the majority of TTX-S current (75.5 ± 10.5%, n = 5, Fig 5D) whilst 100 nM resulted in complete block. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Anti-diabetic Compound Library | Orally Active Compound Library | Neuroprotective Compound Library | Targeted Diversity Library | Sodium Channel Blocker Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Ion Channel Compound Library | Bioactive Compound Library Max | Amiloride hydrochloride | Halofuginone | Carbamazepine | Riluzole | 20(S)-Ginsenoside Rg3 | Lidocaine | TPC2-A1-P | Veratridine | Fluphenazine dihydrochloride | Amitriptyline hydrochloride | Lamotrigine | A-803467 | QX-314 chloride | 5-(N,N-Hexamethylene)-amiloride | Phenytoin | Triamterene | Ranolazine | Flunarizine dihydrochloride | Benzamil hydrochloride | Suzetrigine | Atomoxetine hydrochloride | Vinpocetine | Zandatrigine | Ropivacaine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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