VUF10460 | MedChemExpress (MCE)

VUF10460 产品活性：VUF10460是非咪唑组胺H4受体激动剂; 与大鼠H4受体结合的pKi值为7.46。 产品来源： https://www.medchemexpress.cn/VUF10460.html 研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation 作用靶点：Histamine Receptor In Vitro: UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively. VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor. In Vivo: HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120. 相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Neuronal Signaling Compound Library | Endocrinology Compound Library | Neurotransmitter Receptor Compound Library | Coagulation and Anti-coagulation Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Bioactive Compound Library Max | Histamine | Clemastine fumarate | Astemizole | Cimetidine | Terfenadine | Amitriptyline hydrochloride | Loratadine | Mecamylamine hydrochloride | Desloratadine | Diphenhydramine hydrochloride | Doxepin Hydrochloride | Osthole | Famotidine | Fexofenadine hydrochloride | Perphenazine | (S)-(+)-Dimethindene maleate | Promethazine hydrochloride | Ketotifen fumarate | Benztropine mesylate | Ritanserin | Lodoxamide | Mepyramine maleate | Mianserin hydrochloride | Cetirizine dihydrochloride | Chlorpheniramine maleate | Mirtazapine | Ebastine | JNJ-7777120 | Azelastine hydrochloride | Meclizine dihydrochloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途