PF-4800567 | MedChemExpress (MCE)

PF-4800567 产品活性：PF-4800567 是一种有效、选择性的酪蛋白激酶 1? (CK1?) 抑制剂，IC50 值为 32 nM，对其选择性是对 CK1δ (IC50，711 nM) 的 20 倍。 产品来源： https://www.medchemexpress.cn/PF-4800567.html 研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt 作用靶点：Casein Kinase In Vitro: PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 shows inhibitory activity against CK1? and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM. In Vivo: PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice. 相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Targeted Diversity Library | Chemokine Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Multi-Target Compound Library | Bioactive Compound Library Max | LY294002 | Silmitasertib | IWP-2 | Emodin | Ellagic acid | D4476 | PF-670462 dihydrochloride | Umbralisib | TMX-4116 | TBB | Casein Kinase inhibitor A51 | DMAT | SSTC3 | (E/Z)-GO289 | FPFT-2216 | SR-3029 | IC261 | SGC-CK2-1 | TAK-715 | CKI-7 free base | TTP 22 | BioE-1115 | PF-5006739 | AMG-548 dihydrochloride | CK1-IN-1 | TA-01 | BTX161 | Hematein | CK2/ERK8-IN-1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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