Kira8 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 3042 |
性能特点
Kira8 (AMG-18) 是一种单选择性 IRE1α 抑制剂,可以变构减弱 IRE1α RNase 活性,IC50 为 5.9 nM。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 1630086-20-2 | ¥3,042.00 | 询底价 |
Kira8 产品活性:Kira8 (AMG-18) 是一种单选择性 IRE1α 抑制剂,可以变构减弱 IRE1α RNase 活性,IC50 为 5.9 nM。 产品来源: https://www.medchemexpress.cn/Kira8.html 研究领域:Cell Cycle/DNA Damage 作用靶点:IRE1 In Vitro: Kira8 blocks IRE1α oligomerization, and potently inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs. Kira8 more potently reduces IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2. In Vivo: Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks. ? One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs. 相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Anti-Aging Compound Library | Anti-diabetic Compound Library | Endoplasmic Reticulum Stress Compound Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | Sunitinib | 4μ8C | STF-083010 | IXA4 | MKC8866 | Toyocamycin | KIRA6 | GSK2850163 | APY29 | MKC3946 | B I09 | IXA6 | IRE1α kinase-IN-1 | MKC9989 | IRE1α kinase-IN-2 | Z4P | 3,6-DMAD hydrochloride | KIRA-7 | 6-Bromo-2-hydroxy-3-methoxybenzaldehyde | IRE1α kinase-IN-3 | IRE1α kinase-IN-4 | IRE1α kinase-IN-5 | IRE1α kinase-IN-6 | IRE1α kinase-IN-7 | IRE1α kinase-IN-8 | IRE1α kinase-IN-9 | Kira8 Hydrochloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物;10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;设有专业的实验中心和严格的质控、验证体系;提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;产品的生物活性多经各国客户实验验证;Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;与世界各大制药公司及知名科研机构建立了长期的合作。
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途