USP25/28 inhibitor AZ1 | MedChemExpress (MCE)

USP25/28 inhibitor AZ1 产品活性：USP25/28 inhibitor AZ1 (AZ1) 是一种口服有效，选择性，非竞争性的双重泛素特异性蛋白酶 USP25/28 抑制剂，IC50 分别为 0.7 μM, 0.6 μM。USP25/28 inhibitor AZ1 可减轻小鼠模型的结肠炎和肿瘤发生。 产品来源： https://www.medchemexpress.cn/usp25-28-inhibitor-az1.html 研究领域：Cell Cycle/DNA Damage 作用靶点：Deubiquitinase In Vivo: USP25/28 inhibitor AZ1 (AZ1; 40 mg/kg; gavage; daily; for 7 days) protects from dextran sulfate sodium (DSS)-induced weight loss and diarrhea and impaired colon shortening. USP25/28 inhibitor AZ1 (20 mg/kg/day; gavage; 6 times a week in the 1, 3, 6 weeks) treatment significantly reduces tumor numbers in colons. Expression of Wnt-related genes and levels of pSTAT3 are decreased and levels of SOCS3 are increased in tumors. AZ1 gavage does not alleviate DSS-induced colitis in Usp25-/- mice or the spontaneous colitis of Il10-/- mice. USP25/28 inhibitor AZ1 (20 mg/kg/day; gavage; every 3 days from 13-20 weeks) significantly inhibits tumorigenesis in the colon and prolonged the survival of AOM/Vil-Cre;Trp53fl/fl (VP) mice. AZ1 treatment has minimal effect on tumorigenesis in the USP25-deficient background. 相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Ubiquitination Compound Library | Orally Active Compound Library | Metabolic Enzyme Compound Library | Protease Inhibitor Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | BAY 11-7082 | N-Ethylmaleimide | PR-619 | Spautin-1 | KSQ-4279 | Degrasyn | ML-323 | P005091 | IU1 | 6-Thioguanine | b-AP15 | Capzimin | LDN-57444 | ML364 | MF-094 | DUB-IN-2 | EOAI3402143 | GRL0617 | CMPD-39 | GSK2643943A | P 22077 | XL177A | USP5-IN-1 | GNE-6776 | FT206 | FT709 | 6RK73 | BAY-805 | Thiolutin | GNE-6640 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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