LS-102 | MedChemExpress (MCE)

LS-102 产品活性：LS 102 是一种选择性的 E3 连接酶 synoviolin (Syvn1) 抑制剂。LS-102 抑制 Syvn1 自泛素化，IC50 约为 35 μM，有研究类风湿关节炎的潜力。 产品来源： https://www.medchemexpress.cn/ls-102.html 研究领域：Metabolic Enzyme/Protease 作用靶点：E1/E2/E3 Enzyme In Vitro: LS-102 inhibits proliferation of RSCs with an IC50 of 5.4 μM. LS-102 suppresses proliferation of rheumatoid synovial cells (RSCs) in a Syvn1-dependent manner. LS-102 suppresses polyubiquitination of target proteins of Syvn1, including nuclear factor erythroid 2-related factor 2 (NRF2), V247M α-sarcoglycan mutant, and PGC-1β. LS-102 inhibits E3 ligase activity of Synoviolin (Syvn1). In Vivo: LS-102 (1.3-4 mg/kg; i.p.; daily for 4 weeks) reduces clinical severity scores in a CIA model. 相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Oxygen Sensing Compound Library | Ubiquitination Compound Library | Anti-Liver Cancer Compound Library | Heterocyclic Compound Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Mitophagy Compound Library | Bioactive Compound Library Max | TAK-243 | Nutlin-3a | Subasumstat | Idasanutlin | Navtemadlin | Mezigdomide | ML-792 | PYR-41 | 2-D08 | MD-224 | C25-140 | Siremadlin | Cbl-b-IN-1 | RG7112 | HOIPIN-8 | Milademetan | Indole-3-carbinol | RB-3 | Ginkgolic Acid | Heclin | NSC697923 | Avadomide | PRT4165 | Alrizomadlin | NSC232003 | SZL P1-41 | BI8626 | BI8622 | Skp2 Inhibitor C1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

LS-102 | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供，如您想了解更多关于LS-102 | MedChemExpress (MCE)报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途