C2 Ceramide | C2 神经酰胺 | MedChemExpress (MCE)

C2 Ceramide 产品活性：C2 Ceramide (Ceramide 2) 是一种角质层的主要脂质，也是一种蛋白质磷酸酶 1 (PP1) 的激活剂。C2 Ceramide 还可激活 PP2A 和神经酰胺激活的蛋白磷酸酶 (CAPP)。C2 Ceramide 可诱导细胞分，自噬 autophagy 和凋亡 (apoptosis)，抑制线粒体呼吸链复合物 III (mitochondrial respiratory chain complex III)。C2 Ceramide 是一种皮肤调理剂，可保护表皮屏障免受水分流失。 产品来源： https://www.medchemexpress.cn/c2-ceramide.html 研究领域：Metabolic Enzyme/Protease | Apoptosis | Autophagy 作用靶点：Phosphatase | Mitochondrial Metabolism | Apoptosis | Autophagy In Vitro: C2 Ceramide (5 nM-200 µM; 24 hours; primary mouse osteoblasts) treatment (≤500 nM) promots osteoblast viability, whilst concentrations ≥2 µM significantly reduces osteoblast viability in a dose- and time-dependent manner. C2 Ceramide increases cytoplasmic histone-associated DNA fragments by 5.7- and 11.2-fold at 50 µM and 100 µM C2 Ceramide concentrations respectively in osteoblasts. At these higher concentrations, C2 Ceramide is a potent inducer of apoptosis in osteoblasts. C2 Ceramide up-regulates mRNA expression of angiogenic genes in human dental pulp cells (HDPCs) and increases the migration and capillary tube formation of endothelial cells, whereas PP1 small interfering RNA shows opposite effects. Human dental pulp cells (HDPCs) increases levels of bone morphogenetic protein 2, phosphorylation of Smad 1/5/8, and mRNA expression of runt-related transcription factor 2 and osterix. In Vivo: The PP1 activator C2 Ceramide increases alkaline phosphatase activity, mineralizes nodule formation, and mRNA expression of dentin matrix protein 1 and dentin sialophosphoprotein. In contrast, knockdown by PP1 small interfering RNA inhibits odontoblastic differentiation. 相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Stem Cell Signaling Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Lipid Compound Library | Endocrinology Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Mitochondria-Targeted Compound Library | Glucose Metabolism Compound Library | Cuproptosis Compound Library | Cancer Stem Cells Compound Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Cell Death Library | Extracellular Vesicles (EVs) Compound Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | MitoSOX Red | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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