Zn-DPA-maytansinoid conjugate 1 | MedChemExpress (MCE)

Zn-DPA-maytansinoid conjugate 1 产品活性：Zn-DPA-maytansinoid conjugate 1 是一种类美坦素偶联物，靶向小分子免疫检查点。Zn-DPA-maytansinoid conjugate 1 可诱导肿瘤生长持续消退，使肿瘤微环境 (TME) 恢复活力、变成“发炎热肿瘤”。 产品来源： https://www.medchemexpress.cn/zn-dpa-maytansinoid-conjugate-1.html 研究领域：Cell Cycle/DNA Damage | JAK/STAT Signaling | Stem Cell/Wnt | GPCR/G Protein | Immunology/Inflammation 作用靶点：Checkpoint Kinase (Chk) | STAT | CXCR | CCR In Vitro: Zn-DPA-maytansinoid conjugate 1 (compound 40a) (0-20 mM; 72 h) inhibits the growth of human pancreatic cancer MIA PaCa2 cells and triple-negative breast cancer HCC1806 cells and displays no effect on normal fibroblast (Detroit 551). Zn-DPA-maytansinoid conjugate 1 increases CD8+ T cell infiltration significantly in the tumor mass that sensitized tumors from the intrinsic immune-suppressive TME. Zn-DPA-maytansinoid conjugate 1 induces tumor inflammation-related mRNA expression such as STAT1, CXCL10, CCL5, and CCL2. Zn-DPA-maytansinoid conjugate 1 leads to rejuvenation of TME with enhancement in T cell, macrophage, NK cell, chemokine, and cytokine functions. In Vivo: Zn-DPA-maytansinoid conjugate 1 (compound 40a) (1-2.5 mg/kg; i.v.; twice a week for 2 weeks) effectively shrank the growth of many solid tumors, exerts antipancreatic cancer, anti-triple-negative breast cancer and anti-sorafenib-resistant HCC tumor activities. 相关产品：Stattic | Fludarabine | Pirfenidone | AG490 | Plerixafor | Maraviroc | Cilengitide | SB225002 | Homoharringtonine | Niclosamide | AS1517499 | C188-9 | Artesunate | AMG 487 | Prexasertib | AZD-7762 | Reparixin | TPCA-1 | Colivelin TFA | Kynurenic acid | Napabucasin | RS 504393 | WP1066 | NSC 74859 | STAT5-IN-1 | Butyzamide | Navarixin | Cryptotanshinone | Astaxanthin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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