MRS5698 | MedChemExpress (MCE)

MRS5698 产品活性：MRS5698 是一种选择性 Gi 蛋白偶联 A3 腺苷受体 (A3AR) 激动剂，对于人和小鼠 A3AR 的 Ki 约为 3 nM。MRS5698 可用于疼痛和银屑病的研究。 产品来源： https://www.medchemexpress.cn/mrs5698.html 研究领域：GPCR/G Protein 作用靶点：Adenosine Receptor In Vitro: MRS5698 displays higher affinity and selectivity (>3000-fold) agonist A3R vs. other adenosine receptor (ARs) in both human and mouse. MRS5698 (0.1-10 µM; 1 hours) induces a concentration-dependently robust A3R-mediated cAMP reduction in HEK-293T cells permanently expressing the A3R, regardless the illumination condition. In Vivo: MRS5698 (3 nmol/day; intrathecal injection for 25 days) prevents Oxaliplatin-induced mechano-allodynia and hyperalgesia, and attenuates Oxaliplatin-induced NLRP3/IL-1β neuroinflammation. MRS5698 (1 mg/kg; i.p. at days 2, 3 ) reduces the IL-23 induced (IL23 injected in day 0, 1, 3) ear thickness of C57BL/6N mouse during the third and fourth experimental days. 相关产品：5'-N-Ethylcarboxamidoadenosine | Inosine | Theophylline | CGS 21680 Hydrochloride | ZM241385 | SCH 58261 | Istradefylline | Etrumadenant | BAY 60-6583 | DPCPX | Ciforadenant | Imaradenant | Namodenoson | Regadenoson | Piclidenoson | MRS 1754 | PSB-603 | Adenosine 5'-monophosphate monohydrate | SCH442416 | Nitrobenzylthioinosine | Preladenant | N6-Cyclopentyladenosine | Theobromine | Aminophylline | Derenofylline | MRS 1523 | Ticlopidine hydrochloride | Inupadenant | MRS-1706 | MRS-1191 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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