PU141 | MedChemExpress (MCE)

PU141 产品活性：PU141 是一种选择性的 HAT 抑制剂。PU141 选择性作用于 CBP 和 p300。PU141 可诱导细胞组蛋白低乙酰化并抑制多种肿瘤细胞系生长。具有抗肿瘤活性。 产品来源： https://www.medchemexpress.cn/pu141.html 研究领域：Epigenetics 作用靶点：Histone Acetyltransferase In Vitro: PU141 inhibits cell growth at micromolar concentrations in A431 (epidemoid carcinoma), A549 (alveolar basal epithelial adenocarcinoma), A2780 (ovarian carcinoma), HCT116 (epithelial colon carcinoma), HepG2 (hepatocellular carcinoma), MCF7 (breast carcinoma), SK-N-SH (neuroblastoma), SW480 (colon adenocarcinoma) and U-87MG (epithelial-like glioblastoma-astrocytoma). PU141 causes both histone hypoacetylation and growth inhibition in vitro. PU141 (25 µM) leads to a decrease in SAHA-induced H3K14 and H4K8 hyperacetylation, whereas H3K9 and H4K16 acetylation levels remaine stable after co-treatment of HDAC and HAT inhibitor. The impact on histone acetylation is similar in both SK-N-SH and HCT116 cells. In Vivo: PU141 (25 mg/kg; administered once intraperitoneally for 24 days) exhibits a significant antitumor effects against neuroblastoma xenografts in vivo. 相关产品：Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | Curcumin | Acetaminophen | A-485 | C646 | Remodelin hydrobromide | SGC-CBP30 | WM-3835 | PF-9363 | NSC 228155 | Anacardic Acid | MG 149 | WM-1119 | Butyrolactone 3 | CTB | GNE-781 | PU139 | NEO2734 | NU9056 | Garcinol | CPI-637 | CPI-1612 | CPTH2 | GNE-049 | WM-8014 | TH1834 | YF-2 | GSK 4027 | JQAD1 | TTK21 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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