Ambenonium dichloride tetrahydrate | MedChemExpress (MCE)

Ambenonium dichloride tetrahydrate 产品活性：Ambenonium (WIN 8077) dichloride tetrahydrate 是一种具有口服活性、可逆的 AChE 抑制剂。Ambenonium dichloride tetrahydrate 抑制 AChE，IC50 为 0.7 nM (hAChE)。Ambenonium dichloride tetrahydrate 能够用于对重症肌无力 (Myasthenia Gravis) 的研究。 产品来源： https://www.medchemexpress.cn/ambenonium-dichloride-tetrahydrate.html 研究领域：Neuronal Signaling 作用靶点：Cholinesterase (ChE) In Vitro: Ambenonium dichloride tetrahydrate inhibits Acetyicholinesterase (AChE) in a rapidly reversible method, and shows strong inhibition with inhibition constant Ki of 0.12 nM against hAChE. Ambenonium dichloride tetrahydrate shows inhibitory effect towards BChE with an IC50 value of 7 μM (hBChE). In Vivo: Ambenonium dichloride tetrahydrate (6 mg/kg; p.o.; daily; 30-60 d) results an adverse effect on neuromuscular transmission in long-term administration, and induces hypersensitivity to stimulation in myasthenia gravis mice modle. Ambenonium dichloride tetrahydrate (6 mg/kg; p.o.; daily; 14 d) decreases the number of AChR in motorend-plates. 相关产品：Dimethyl sulfoxide | Donepezil Hydrochloride | TMPyP4 tosylate | α-NETA | Galanthamine | Physostigmine salicylate | Scopoletin | Garcinol | Rivastigmine | (-)-Huperzine A | Protopine | Protriptyline hydrochloride | sn-Glycero-3-phosphocholine | Imperatorin | Acetylcholinesterase, Fly head | Hemicholinium 3 | Tacrine hydrochloride | Demethoxycurcumin | Linarin | Tacrine | Timosaponin AIII | Corynoline | Epiberberine chloride | Pyridostigmine bromide | Sinapine | Buntanetap | Isoimperatorin | Corydaline 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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