Mupirocin calcium | MedChemExpress (MCE)

Mupirocin calcium 产品活性：Mupirocin (BRL-4910A, Pseudomonic acid) calcium 可从 Pseudomonas fluorescens 中分离得到，是一种有口服活性的抗生素。Mupirocin calcium 通过可逆地抑制异亮氨酸转移 RNA，从而抑制细菌蛋白和 RNA 的合成而发挥抗菌作用。 产品来源： https://www.medchemexpress.cn/mupirocin-calcium.html 研究领域：Anti-infection 作用靶点：Antibiotic | Bacterial In Vitro: Mupirocin (BRL-4910A, Pseudomonic acid) calcium (0-100 μM; 48 h) shows antibacterial effect against staphylococci, streptococci and certain gram-negative bacteria, with MIC values range from 0.06-0.25 μg/mL (MIC50 =0.12 μg/mL, MIC90 =0.25 μg/mL). Mupirocin calcium is highly bound (95% bound) to human serum protein, thus results in activity inhibition in the presence of human serum. Mupirocin calcium apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis. Mupirocin calcium (2% ointment) reduces pro-inflammatory cytokines IL-1β and IL-17 level, decreases tumor necrosis factor-alpha (TNF-α) expression, and increases the leavel of vascular endothelial growth factor (VEGF). Mupirocin calcium inhibits MS (S. epidermidis ATCC 12228), MR (S. epidermidis (Se56-99)), and VIR (S. epidermidis (Se43-98)) with MICs of 0.25, 1.26, 1.59 mg/L. Note: MIC, the minimum inhibition concentration. In Vivo: MRSA: Meticillin-resistant Staphylococcus aureus Mupirocin (BRL-4910A, Pseudomonic acid) calcium is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A. Mupirocin calcium (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment. Mupirocin calcium (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice. Mupirocin calcium (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis. 相关产品：Rapamycin | Cycloheximide | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | Dimethyl sulfoxide | Dexamethasone | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Etoposide | G-418 disulfate | Nigericin sodium salt | Cyclosporin A | 5-Azacytidine | Brefeldin A | CCCP | Estradiol | Bleomycin sulfate | Ionomycin | Hygromycin B | Mitomycin C | Resveratrol | Tunicamycin | Everolimus | Doxycycline hyclate | Tacrolimus | Oligomycin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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