(S)-Volinanserin | MedChemExpress (MCE)

(S)-Volinanserin 产品活性：(S)-Volinanserin 是 Volinanserin (HY-14940) 的一种异构体。Volinanserin 是一种有效的，选择性的 5-HT2 受体拮抗剂，Ki 值为 0.36 nM，对其选择性是对 5-HT1c，alpha-1 和 DA D2 受体的 300 倍，可用于精神疾病的研究。 产品来源： https://www.medchemexpress.cn/s-volinanserin.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：5-HT Receptor In Vitro: Volinanserin (MDL 100907) is a potent antagonist at the 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c receptor, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity. In Vivo: Volinanserin (MDL 100907; 0.008-2.0 mg/kg, i.p.) significantly decreases d-amphetamine-stimulated locomotor activity in mice, with an ED50 of 0.3 mg/kg, but shows no obvious reduction in the base-line locomotor activity in mice. Volinanserin produces atalepsy with an ED50 of 10-50 mg/kg in rats. Volinanserin does not reduces apomorphine-induced stereotypies or produces catalepsy in rats. Volinanserin (M100907) combined with MK-801 significantly decreases reinforcers at 1 μg/kg, but dose-dependently (10, 100 μg/kg) antagonizes the disruptive effect of MK-801 in rats via i.p. administration. Volinanserin (6.25 μg/kg) enhances the antidepressant-like action of Desipramine (HY-B1272A) in rats performing under a DRL 72-s schedule, and elevates the antidepressant-like effect of Tranylcypromine (HY-17447). 相关产品：Chlorpromazine hydrochloride | Serotonin hydrochloride | SCH-23390 hydrochloride | Harmine | Puerarin | PNU-282987 | Scopolamine hydrobromide | Clozapine | Risperidone | Vortioxetine | Olanzapine | Dihydroergotamine mesylate | Aripiprazole | GTS-21 dihydrochloride | Amitriptyline hydrochloride | Ondansetron | Thioridazine hydrochloride | Brexpiprazole | SB-269970 hydrochloride | Cisapride | SEP-363856 hydrochloride | Volinanserin | Vilazodone Hydrochloride | Pimavanserin | 8-OH-DPAT | Ketanserin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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