RyR2 stabilizer-1 | MedChemExpress (MCE)

RyR2 stabilizer-1 产品活性：RyR2 stabilizer-1 (化合物12a) 是一种有效的 RyR2 稳定剂和 SERCA2a 激活剂，对 RyR2 和 SERCA2 的 EC50 分别为 2.7 μM 和 383 nM。RyR2 stabilizer-1 抑制 Ca2+ 从 SR RyR2 渗漏，同时促进 SERCA2 将 Ca2+ 泵回 SR，这使 RyR2 stabilizer-1 有预防心律失常的可能。 产品来源： https://www.medchemexpress.cn/ryr2-stabilizer-1.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：Calcium Channel In Vitro: RyR2 stabilizer-1 (0-100 μM) significantly increases [Ca2+]ER dose-dependently, at concentrations above 25 μM RyR2 stabilizer-1 demonstrates the most pronounced effect. RyR2 stabilizer-1 has EC50s of 383 nM, 9.2 μM and 16 nM for SERCA2a in mouse SR, HL-1 and HEK ER, respectively. RyR2 stabilizer-1 (10 μM, incubated for 2 h) improves HL-1 SERCA2a activity in the caffeine-induced Ca2+ release assay. RyR2 stabilizer-1 (50 μM, HL-1, 24h) shows no significant cell death in CytoTox-Glo Cytotoxicity Assay. RyR2 stabilizer-1 (100 μM, 5min) causes a strong decrease in NADH fluorescence which reflecting an increase in SERCA2a activity in SR microsomes derived from mouse heart ventricles, it also causes the improvement of ATPase activity . 相关产品：Thapsigargin | Ionomycin | L-Ascorbic acid | Minocycline hydrochloride | Verapamil | 2-Aminoethyl diphenylborinate | Acetylcholine chloride | GSK1016790A | Nifedipine | Fasudil Hydrochloride | Ebselen | Halofuginone | Bay K 8644 | Carbamazepine | Tetrandrine | Ruthenium red | L-Phenylalanine | ISX-9 | Gabapentin | Amlodipine | CDN1163 | TPC2-A1-N | Ethacrynic acid | Cromolyn sodium | Dantrolene | Diltiazem hydrochloride | Taurolithocholic acid sodium salt 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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