耗材描述

• 分子式 C₂₆H₃₃NO₂
• 分子量391.55

属性

溶解性	Soluble in methanol (sparingly), water (<1 mg/ml at 25 °C), DMF (~16 mg/ml), ethanol (28 mg/ml at 25 °C), and DMSO (~2 mg/ml).
存贮条件	储存温度-20°C

描述

应用	A steroidal inhibitor of CYP17A1 in androgen biosynthesis
产品介绍	Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂，IC50为72 nM。
备注	Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM.
生化机理	Abiraterone acetate has been seen to be a novel steroidal inhibitor of CYP17A1(C17,20 lyase), a cytoochrome P450 complex, a rate-limiting enzyme in androgen biosynthesis resulting in inhibtion of testosterone production in both the adrenals and the testes. It has been observed to decrease the DHEA, androstenedione and testosterone. The compound has been shown to be approximately 21-24 times more potent than ketoconazole and liarozole in CYP17A1 lyase inhibition. In medicine, Abiraterone is used for treating prostate cancer.
别名	乙酸阿比特龙酯;CB 7630, CB-7630;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

猜你喜欢

• 

  盐酸尼莫司汀

• 

  Mildronate dihydrate

• 

  Ferrostatin-1 (Fer-1)

• 

  4-丁基间苯二酚

• 

  噻克索酮

• 

  Gimeracil

• 

  Dalcetrapib

• 

  Methotrexate

• 

  LCQ-908

• 

  Clarithromycin

感兴趣产品

• Abiraterone Acetate价格
• Abiraterone Acetate厂商
• Abiraterone Acetate规格