化合物 T12819 T12819
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Product IntroductionBioactivity英文名: S130描述: S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor
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Product Introduction
Bioactivity
英文名: S130
描述: S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
体外活性: S130 suppresses autophagy and activates apoptosis by inhibiting ATG4B, leads to enhanced cytotoxicity. S130 (0-25 μM; 48 hours) induces cell death through inhibiting the activity of ATG4B at a dose higher than 6.3 μM. And such cytotoxicity might not cause cell death through necroptosis. Nutrient deprivation enhances S130-induced cytotoxicity. S130 (0-10μM; 24 hours) suppresses approximately 79% of the cleavage of full-length LC3-GST at the 10 μM, while no substrates were processed in ATG4B KO cells. S130 displays obvious inhibitory effects on ATG4B.
体内活性: Tumor growth suppressed by S130 (20 mg/kg; i.p.; daily; 3 weeks), S130 shows an efficient in vivo antitumor effect with a sound safety on vital organs.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 125 mg/mL (322.61 mM)
关键字: S-130 | S 130 | S130
相关产品: Aurantiamide acetate | Z-FA-FMK | CA-074 methyl ester | PD 151746 | Z-Lys-OH | E-64 | Leupeptin Hemisulfate | Isovalerylcarnitine | PMSF | 3,4 Dichloroisocoumarin
Bioactivity
英文名: S130
描述: S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
体外活性: S130 suppresses autophagy and activates apoptosis by inhibiting ATG4B, leads to enhanced cytotoxicity. S130 (0-25 μM; 48 hours) induces cell death through inhibiting the activity of ATG4B at a dose higher than 6.3 μM. And such cytotoxicity might not cause cell death through necroptosis. Nutrient deprivation enhances S130-induced cytotoxicity. S130 (0-10μM; 24 hours) suppresses approximately 79% of the cleavage of full-length LC3-GST at the 10 μM, while no substrates were processed in ATG4B KO cells. S130 displays obvious inhibitory effects on ATG4B.
体内活性: Tumor growth suppressed by S130 (20 mg/kg; i.p.; daily; 3 weeks), S130 shows an efficient in vivo antitumor effect with a sound safety on vital organs.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 125 mg/mL (322.61 mM)
关键字: S-130 | S 130 | S130
相关产品: Aurantiamide acetate | Z-FA-FMK | CA-074 methyl ester | PD 151746 | Z-Lys-OH | E-64 | Leupeptin Hemisulfate | Isovalerylcarnitine | PMSF | 3,4 Dichloroisocoumarin
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