P125444-25mgPelitinib
面议
- 阿拉丁
- 生产商
- P125444-25mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C24H23ClFN5O2
- 分子量467.92
属性
溶解性 | Soluble in DMSO (13 mg/ml at 25 °C), methanol, water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
存贮条件 | 储存温度-20°C |
描述
应用 | An EGFR inhibitor |
产品介绍 | Pelitinib (EKB-569)是一种有效的,不可逆EGFR抑制剂,IC50为38.5 nM。 |
备注 | Pelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Phase2. |
生化机理 | Pelitinib is a tyrosine kinase inhibitor that covalently binds to EGFR, inhibiting receptor phosphorylation and thus inhibiting signal transduction from EGFR. This induces apoptosis and thus leads to suppression of growth in tumor cell lines. |
别名 | EKB-569;培利替尼; 贝利替尼; (2E)-N-[4-[(3-氯-4-氟苯基)氨基]-3-氰基-7-乙氧基-6-喹啉基]-4-(二甲基氨基)-2-丁烯酰胺;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;EKB 569;EKB-569;WAY-EKB-569 |
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